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【medical-news】阿司匹林可预防成人新发哮喘

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楼主 lwjssry
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这个帖子发布于14年零13天前,其中的信息可能已发生改变或有所发展。
Aspirin May Prevent New Adult-Onset Asthma
NEW YORK (Reuters Health) Jan 15 - Results from the Physicians Health Study indicate that regular aspirin use may reduce the risk of new-onset asthma in adults by 22%. However, there is no evidence that aspirin improves symptoms in subjects who already have asthma, and it may of course cause acute bronchospasm among individuals with aspirin-intolerant asthma.

As reported in the January issue of the American Journal of Respiratory and Critical Care Medicine, Dr. Tobias Kurth, at Brigham and Women's Hospital in Boston, and associates examined data from the Physicians' Health Study, which at one point involved more than 22,000 men randomized to aspirin or placebo.

The healthy subjects, aged 40 to 84 years and free of asthma at baseline in 1982, were randomly assigned on a one-to-one basis of a single 325-mg tablet of aspirin or placebo on alternate days. This aspect of the study was terminated after an average of 4.9 years because of the reduction in risk of a first MI associated with aspirin use.

The risk of newly diagnosed asthma was reduced by 22% in the aspirin arm of the study (n = 113 versus 145, p = 0.045). The investigators' stratified analysis showed that the reduction in new diagnoses of asthma was greater among those who had never smoked (p = 0.049) and among those who were < 45.9 years old at baseline (p = 0.01).

Dr. Kurth and his associates point out that aspirin-intolerant asthma affects 4% to 11% of asthma patients, particularly adults, who may respond to an aspirin challenge with severe bronchospasm.

So, while the researchers propose that aspirin may decrease the onset of asthma in adults, they absolutely "do not imply that aspirin improves symptoms in patients with asthma."

Am J Respir Crit Care Med 2007;175:120-125.

http://www.medscape.com/viewarticle/550787
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2007-01-16 13:05 浏览 : 1597 回复 : 3
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lwjssry 编辑于 2007-01-16 14:37
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Aspirin May Prevent New Adult-Onset Asthma
阿司匹林可预防成人新发哮喘

NEW YORK (Reuters Health) Jan 15 - Results from the Physicians Health Study indicate that regular aspirin use may reduce the risk of new-onset asthma in adults by 22%. However, there is no evidence that aspirin improves symptoms in subjects who already have asthma, and it may of course cause acute bronchospasm among individuals with aspirin-intolerant asthma.
纽约路透社健康栏目1月15日消息:来自医师健康研究(the Physicians Health Study)的研究结果显示,规律服用阿司匹林可使成人新发哮喘的发病风险降低22%,但并无证据显示阿司匹林可改善哮喘症状。另外阿司匹林可引发阿司匹林不适应性哮喘患者出现急性支气管痉挛。

As reported in the January issue of the American Journal of Respiratory and Critical Care Medicine, Dr. Tobias Kurth, at Brigham and Women's Hospital in Boston, and associates examined data from the Physicians' Health Study, which at one point involved more than 22,000 men randomized to aspirin or placebo.
该研究发表在一月份American Journal of Respiratory and Critical Care Medicine杂志上。作为师健康研究的一部分,22000多名男性随机分配到阿司匹林处理组和安慰剂组。来自波士顿Brigham and Women's Hospital的Dr. Tobias Kurth及其同事对这部分数据进行了研究。

The healthy subjects, aged 40 to 84 years and free of asthma at baseline in 1982, were randomly assigned on a one-to-one basis of a single 325-mg tablet of aspirin or placebo on alternate days. This aspect of the study was terminated after an average of 4.9 years because of the reduction in risk of a first MI associated with aspirin use.
该研究以1982年为基线,此前无哮喘的40-84岁之间的健康的受试者被一一对应地随机分配到处理组和对照组,隔天分别给予一片325毫克阿司匹林或安慰剂。因为使用阿司匹林会引起相关的初发 MI(myocardial infarction,心肌梗塞)发病风险降低,医师健康研究的该部分于平均4.9年后被终止。

The risk of newly diagnosed asthma was reduced by 22% in the aspirin arm of the study (n = 113 versus 145, p = 0.045). The investigators' stratified analysis showed that the reduction in new diagnoses of asthma was greater among those who had never smoked (p = 0.049) and among those who were < 45.9 years old at baseline (p = 0.01).
该研究提示,阿司匹林处理组新发哮喘的发病风险下降22%(n = 113 versus 145, p = 0.045)。而分层分析显示,从不吸烟者(p = 0.049)以及基线时年龄< 45.9岁者(p = 0.01),其新发哮喘发病风险的下降则更为明显。

Dr. Kurth and his associates point out that aspirin-intolerant asthma affects 4% to 11% of asthma patients, particularly adults, who may respond to an aspirin challenge with severe bronchospasm.
Dr. Kurth和他的同事们指出,哮喘患者,特别是成年患者中,4%至11%为阿司匹林不适应性哮喘,这种阿司匹林不适应性哮喘可诱发严重的支气管痉挛。

So, while the researchers propose that aspirin may decrease the onset of asthma in adults, they absolutely "do not imply that aspirin improves symptoms in patients with asthma."
因此,虽然研究人员提出阿司匹林可降低成人新发哮喘的发病率,但他们完全“不认为阿司匹林可改善哮喘患者的症状”。
2007-01-16 13:05
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lwjssry 编辑于 2007-01-16 14:38
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阿司匹林可预防成人新发哮喘
纽约路透社健康栏目1月15日消息:来自医师健康研究(the Physicians Health Study)的研究结果显示,规律服用阿司匹林可使成人新发哮喘的发病风险降低22%,但并无证据显示阿司匹林可改善哮喘症状。另外阿司匹林可引发阿司匹林不适应性哮喘患者出现急性支气管痉挛。
该研究发表在一月份American Journal of Respiratory and Critical Care Medicine杂志上。作为师健康研究的一部分,22000多名男性随机分配到阿司匹林处理组和安慰剂组。来自波士顿Brigham and Women's Hospital的Dr. Tobias Kurth及其同事对这部分数据进行了研究。
该研究以1982年为基线,此前无哮喘的40-84岁之间的健康的受试者被一一对应地随机分配到处理组和对照组,隔天分别给予一片325毫克阿司匹林或安慰剂。因为使用阿司匹林会引起相关的初发 MI(myocardial infarction,心肌梗塞)发病风险降低,医师健康研究的该部分于平均4.9年后被终止。
该研究提示,阿司匹林处理组新发哮喘的发病风险下降22%(n = 113 versus 145, p = 0.045)。而分层分析显示,从不吸烟者(p = 0.049)以及基线时年龄< 45.9岁者(p = 0.01),其新发哮喘发病风险的下降则更为明显。
Dr. Kurth和他的同事们指出,哮喘患者,特别是成年患者中,4%至11%为阿司匹林不适应性哮喘,这种阿司匹林不适应性哮喘可诱发严重的支气管痉挛。
因此,虽然研究人员提出阿司匹林可降低成人新发哮喘的发病率,但他们完全“不认为阿司匹林可改善哮喘患者的症状”。
2007-01-16 14:39
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  • • 【规培笔记128】—工作报告偶遇,颅脑MR,据说工作中很罕见——肾性脑病!
楼主 lwjssry
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刚刚发现重了
http://www.dxy.cn/bbs/post/view?bid=116&id=8069145&sty=1&tpg=1&age=0
消息源自不同的来源,主要内容相同,但表述有异,所以搜索一下并没看到重复
2007-01-16 17:23
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  • • 2021年上海市医学会呼吸分会病例讨论(上海东方医院提供,1.27揭秘)

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