发帖
每发1个新帖
可以获得0.5个丁当奖励
回帖

☆☆欢迎参加内分泌期刊文摘翻译第7期☆☆

只看楼主
页码直达：
直达末页

常驻站友

+1 积分
124楼

第41篇
校对
41.生活方式的干预可持续降低2型糖尿病发病率：一项芬兰糖尿病防治研究的随访
背景
生活方式的干预，至少在干预持续进行期间，可防止糖耐量减低的恶化并发展为明确2型糖尿病。在芬兰糖尿病防治研究的扩大随访中，我们评估了那些已初步完成生活方式的改变并在终止积极的健康咨询后危险降低效应仍在持续的人。
方法
糖耐量减低且超重的中年男子172人和女子350人被随机分配到加强生活方式干预组和对照组。经过平均4年的积极干预期后，仍未能诊断为糖尿病的参与者继续随访平均3年，总共持续平均7年。检测糖尿病发病率、体重、体育锻炼和饮食中脂肪、饱和脂肪及纤维素的摄入。
结果
在整个随访中，2型糖尿病的发病率在干预组和对照组中分别为4.3%和7.4%（秩和检验 P=0.0001），说明与此相关的危险程度可降低43%。这种危险度的下降与干预方式成功地取得预期结果如体重下降、总脂肪和饱和脂肪的摄入降低和膳食纤维摄入增多，体育锻炼的加强有关。在干预组中，在参与者终止干预后，仍能保持有益的生活方式的改变，其终止干预后随访的发病率相应为4.6%和7.2%（P=0.0401），说明与此相关的危险程度可降低36%。
解释
在2型糖尿病高危人群中通过生活方式的干预可让在其维持生活方式的改变并减少糖尿病发病率，即使在停止提供对于其个人生活方式的建议后。

41.doc(26.0k)

2006-12-08 22:28

投票
收藏
打赏
引用
分享
- 微信扫一扫
- 新浪微博
- 丁香客
- 复制网址
举报
- 广告宣传推广
- 政治敏感、违法虚假信息
- 恶意灌水、重复发帖
- 违规侵权、站友争执
- 附件异常、链接失效
- 其他

piner 编辑于 2006-12-08 22:33

• 我可能是试工里最主动最傻的那一个

游客

入门站友

+2 积分
125楼

dazongshi
　　第7期内分泌期刊文摘翻译活动又和大家见面了，希望各位站友踊跃参加！
　　本次内分泌文摘仍来源于 Diabetes、Diabetes Care、Diabetologia、Endocrine Review、New England Journal of Medicine 、Journal of the American Medical Association 、The Journal of Clinical Endocrinoloy & Metabolism 等杂志，选取内分泌临床、基础方面的研究进展共50篇（具体见附件）。具体活动规则、翻译及校对格式和以前相同（具体要求见后）。
　　需要说明的是，文摘翻译活动的目的是为促进各位站友共同学习、进步。希望各位站友对译文的质量进行精益求精的要求，不要单纯以挣取积分为目的。
　　谢谢各位站友合作！

活动规则
　　1、翻译一篇加一分。
　　2、校对一篇加一分。
　　3、很有价值的点评视具体情况加分。
　　4、 翻译认领一人最多4篇，校对认领一人最多3篇，校对时，同一篇最多可有2人认领 。
　　5、有关校对的特别说明：与原翻译至少有4处以上不同之处，或者不同之处4处以下，但是是原翻译明显错译处才能加分。
　　6、先认领，后完成工作，认领之日起7天内贴出翻译稿，如有特殊原因不能如期完成的朋友请PM我，如果没有收到PM，则取消原认领。
　　7、所有站友认领翻译及译文校对时，请务必以回帖形式认领，PM认领视为无效认领。

翻译及校对格式

　　 翻译格式：
　　请先贴出英文，后贴出中文译稿样本如下：

Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients pp 648 - 652
L. L. J. Koppes1, 2 , J. M. Dekker1, H. F. J. Hendriks3, L. M. Bouter1 and R. J. Heine1, 4
Aims/hypothesis This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited.
Materials and methods A PubMed search through to September 2005 was performed and the reference lists of relevant articles examined. Among the relevant articles there were six cohort studies reporting on the risk of total mortality and/or fatal and/or incident CHD in alcohol non-consumers and in at least two groups of alcohol consumers.
Results Statistical pooling showed lower risks in alcohol consumers than in non-consumers (the reference category). The relative risk (RR) of total mortality was 0.64 (95% CI 0.49–0.82) in the <6 g/day category. In the higher alcohol consumption categories (6 to <18, and ≥18 g/day), the RRs of total mortality were not significant. Risks of fatal and total CHD were significantly lower in all three categories of alcohol consumers (<6, 6 to <18 and ≥18 g/day) than in non-consumers, with RRs ranging from 0.34 to 0.75.
Conclusions/interpretation This meta-analysis shows that, as with findings in the general population, moderate alcohol consumption is associated with a lower risk of mortality and CHD in type 2 diabetic populations.

饮酒与2型糖尿病患者冠心病和死亡率的Meta分析

目的/假设：这个系统评价是研究酒精消耗和2型糖尿病长期并发症的关系。由于关于2型糖尿病其它并发症的文章太少，不能得到相关文章，故本系统评价的观察指标仅采用了总死亡率、冠心病致死率和冠心病发生率。

材料与方法：在PubMed中检索的截止时间是2005年9月，而且检索了参考文献中的相关文章。在所有相关的文献中有6篇研究报道了无嗜酒嗜好者和至少2组酒精消耗者的总死亡率和/或致死性和/或突发性冠心病的危险性。

结果：合并统计分析结果示酒精消耗者较对照组非酒精消耗者危险性低。每天摄入6克酒精者总死亡率的相对危险性（RR）为0.64 (95% CI 0.49–0.82)。酒精摄入较多者（6克<每天摄入酒精量<18克，和≥18 克）总死亡率的相对危险性无统计学差异。致死性冠心病和总冠心病发病率的危险性在三组酒精消耗组（<6, 6 to <18 and ≥18 克/天)均明显低于非酒精消耗组，相对危险性（RR）的范围为0.34至 0.75。

结论/解释：跟其它一般人群的发现一样，本系统评价发现适度的酒精摄入可降低2型糖尿病患者的死亡率和冠心病的发病率。

　　 校对格式：
　　用红色部分标示出与原文不一样的地方。
　　样本如下：
第40篇
胎儿时期雄激素过多导致多囊卵巢综合症机制的回顾性研究：由实验、临床及遗传联合研究获得的证据
背景：多囊卵巢综合症（PCOS）是一种绝经前妇女常见的内分泌疾病，其特征为雄性激素过多、多囊卵巢以及持续无排卵，并伴随有胰岛素抵抗、腹部肥胖等常见代谢性疾病特征。尽管PCOS在临床上青春期期间表现最为明显，但是最新资料提示PCOS可能源于在子宫内的胎儿时期。
证据采集：对来自实验、临床及遗传方面研究并支持PCOS起源于胎儿时期假说的证据进行分析。
证据综合：在子宫内受雄激素过多影响的雌性灵长类动物，在成年时期会出现PCOS的表型特征。临床观察也支持胎儿时期可有潜在的PCOS起源。胎儿期出现雄激素过多症（包括先天性21-羟化酶缺乏症及先天性肾上腺女子男性化肿瘤）的女性，尽管出生后雄激素分泌恢复正常，但是仍然会在成年时期出现PCOS的典型特征。胎儿期雄性激素过多导致PCOS表型的潜在机制目前还不是很清楚。但无论如何，母体和/或胎儿的雄性激素过多症可以对胎儿期形成PCOS提供了似乎较为合理的解释，而且在一定程度上讲，可能是由遗传所决定的。因而，遗传相关的研究提示，通常决定雄激素活性或影响雄激素对靶器官效果的基因的多态变异体，与PCOS及雄激素水平升高有关。这些基因组的变异可以对人PCOS产前雄激素化提供遗传方面的联系。
结论：遗传因素和环境因素，或二者相互作用诱导的雌性胎儿的产前雄激素化，可以作用于不同的靶组织而产生成人时期不同的PCOS表型。

关于回帖编辑方法（用红色部分标示方法）请参考：
http://www.dxy.cn/bbs/thread/458918

2.Low-Carbohydrate-Diet Score and the Risk of Coronary Heart Disease in Women
Thomas L. Halton, Sc.D., Walter C. Willett, M.D., Dr.P.H., Simin Liu, M.D., Sc.D., JoAnn E. Manson, M.D., Dr.P.H., Christine M. Albert, M.D., M.P.H., Kathryn Rexrode, M.D., and Frank B. Hu, M.D., Ph.D.
Background Low-carbohydrate diets have been advocated for weight loss and to prevent obesity, but the long-term safety of these diets has not been determined.
Methods We evaluated data on 82,802 women in the Nurses' Health Study who had completed a validated food-frequency questionnaire. Data from the questionnaire were used to calculate a low-carbohydrate-diet score, which was based on the percentage of energy as carbohydrate, fat, and protein (a higher score reflects a higher intake of fat and protein and a lower intake of carbohydrate). The association between the low-carbohydrate-diet score and the risk of coronary heart disease was examined.
Results During 20 years of follow-up, we documented 1994 new cases of coronary heart disease. After multivariate adjustment, the relative risk of coronary heart disease comparing highest and lowest deciles of the low-carbohydrate-diet score was 0.94 (95% confidence interval [CI], 0.76 to 1.18; P for trend=0.19). The relative risk comparing highest and lowest deciles of a low-carbohydrate-diet score on the basis of the percentage of energy from carbohydrate, animal protein, and animal fat was 0.94 (95% CI, 0.74 to 1.19; P for trend=0.52), whereas the relative risk on the basis of the percentage of energy from intake of carbohydrates, vegetable protein, and vegetable fat was 0.70 (95% CI, 0.56 to 0.88; P for trend=0.002). A higher glycemic load was strongly associated with an increased risk of coronary heart disease (relative risk comparing highest and lowest deciles, 1.90; 95% CI, 1.15 to 3.15; P for trend=0.003).
Conclusions Our findings suggest that diets lower in carbohydrate and higher in protein and fat are not associated with increased risk of coronary heart disease in women. When vegetable sources of fat and protein are chosen, these diets may moderately reduce the risk of coronary heart disease.
Xioatu 初译
翻译：低碳水化合物膳食评分与妇女患冠心病的风险
背景低碳水化合物饮食曾被用于减肥及治疗肥胖症，但这种饮食长期的安全性尚有待证实。
方法我们评估数据是来源于Nurses'健康研究的82,820位妇女完成的有效饮食频率调查表。以碳水化合物、脂肪及蛋白质各自的产能比为基础（高分代表高脂肪高蛋白质及低碳水化合物膳食），利用调查表的数据计算低碳水化合物膳食的评分，研究低碳水化合物饮食评分与冠心病风险之间的相关性。
结论在20年的随访中，我们证实了1994例新发冠心病患者。经过多元校正后，与最高和最低的低碳水化合物饮食评分的十分位数比较，冠心病的相对危险度为0.94（95％可信区间，0.76~1.18，P趋近于等于 0.19）。以从摄入碳水化合物、动物性蛋白，动物性脂肪供能百分比为基础，与最高和最低的低碳水化合物饮食评分的十分位数比较，相对危险度为0.94（95％可信区间，0.74~1.19，P趋近于等于 0.52），而以摄入碳水化合物、植物性蛋白、植物性脂肪作为供能百分比为基础，冠心病的相对危险度为0.70（95％可信区间，0.56~0.88，P趋近于等于 0.002）。较高的糖负荷与患冠心病的风险增高有密切的联系（相关风险最高至最低的十分位数为1.90; 95％可信区间, 1.15~3.15，P趋近于等于 0.003）。
结论本研究表明低碳水化合物及高脂高蛋白膳食与妇女患冠心病的风险增高无相关性。当以植物源性脂肪及蛋白质作为能量供给时，这些饮食似乎可以适度的减低患冠心病的风险。

23.Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency
Yong Qi, Zhenying Nie, Yun-Sik Lee, Neel S. Singhal, Philipp E. Scherer, Mitchell A. Lazar, and Rexford S. Ahima
Diabetes 2006 55: 3083-3090.
Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis in rodents. Here, we have determined the role of resistin in ob/ob mice that are obese and insulin resistant because of genetic deficiency of leptin. Loss of resistin increased obesity in ob/ob mice by further lowering the metabolic rate without affecting food intake. Nevertheless, resistin deficiency improved glucose tolerance and insulin sensitivity in these severely obese mice, largely by enhancing insulin-mediated glucose disposal in muscle and adipose tissue. In contrast, in C57BL/6J mice with diet-induced obesity but wild-type leptin alleles, resistin deficiency reduced hepatic glucose production and increased peripheral glucose uptake. Resistin deficiency enhanced Akt phosphorylation in muscle and liver and decreased suppressor of cytokine signaling-3 level in muscle, and these changes were reversed by resistin replacement. Together, these results provide strong support for an important role of resistin in insulin resistance and diabetes associated with genetic or diet-induced obesity.

88kg初译
抵抗素的减少可以改善瘦素缺乏者的血糖稳定性
抵抗素水平不仅在肥胖者中增高，且高抵抗素血症在啮齿类动物中可降低血糖的稳定性。我们已经确定了抵抗素在瘦素基因敲除的肥胖、胰岛素抵抗的ob/ob小鼠中的作用。抵抗素缺乏降低了代谢率而不影响摄食，从而加重了ob/ob小鼠的肥胖。但是，抵抗素缺乏改善了这些严重肥胖小鼠的糖耐量和胰岛素敏感性，主要是通过加强了胰岛素介导的肌肉和脂肪组织对葡萄糖的利用。相反的，在含有野生型瘦素基因的饮食诱导肥胖的C57BL/6J小鼠，抵抗素缺乏减少了肝糖生成并增加了外周血葡萄糖的摄取。抵抗素缺乏加强了肌肉和肝脏的Akt磷酸化，并减少了肌肉的细胞因子信号3传到途径的抑制因子水平，这些表现可以通过增加抵抗素水平逆转。综上，这些结果为抵抗素在基因缺陷或饮食诱导的肥胖相关的胰岛素抵抗和糖尿病中的重要作用提供了强有力的支持。

新建 Microsoft Word 文档.doc(25.5k)

2006-12-09 23:01

投票
收藏
打赏
引用
分享
- 微信扫一扫
- 新浪微博
- 丁香客
- 复制网址
举报
- 广告宣传推广
- 政治敏感、违法虚假信息
- 恶意灌水、重复发帖
- 违规侵权、站友争执
- 附件异常、链接失效
- 其他

• 【规培笔记128】—工作报告偶遇，颅脑MR，据说工作中很罕见——肾性脑病！

谷子

内分泌科

铁杆站友

+1 积分
126楼

由于我下不了翻译摘要的原文(word文件)，只能下版主所附的翻译7期整理文档(RAR文件)来翻译，没想到版主所附的翻译7期整理文档中所列的第50篇题目与摘要不一致，我翻译完了才反应过来，仔细一看原来是第49篇的摘要，白费了功夫！还是贴上去算了,就当较对吧。
不知什么原因下不了原文word文件，请版主给我的邮箱发一份吧，得抓紧翻第50篇，快过期了。chengshiwu@sina.com

第4篇翻译
4.CLINICAL PRACTICE GUIDELINE: Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline

Objective: The objective was to provide guidelines for the therapeutic use of androgens in women

Participants: The Task Force was composed of a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, six additional experts, a methodologist, and a medical writer. The Task Force received no corporate funding or remuneration.

Evidence: The Task Force used systematic reviews of available evidence to inform its key recommendations. The Task Force used consistent language and graphical descriptions of both the strength of recommendation and the quality of evidence, using the recommendations of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) group. The strength of a recommendation is indicated by the number 1 (strong recommendation, associated with the phrase "we recommend") or 2 (weak recommendation, associated with the phrase "we suggest"). The quality of the evidence is indicated by cross-filled circles, such that denotes very-low-quality evidence, low quality, moderate quality, and high quality. Each recommendation is followed by a description of the evidence.

Consensus Process: Consensus was guided by systematic reviews of evidence and discussions during one group meeting, several conference calls, and e-mail communications. The drafts prepared by the task force with the help of a medical writer were reviewed successively by The Endocrine Society’s CGS, Clinical Affairs Committee (CAC), and Executive Committee. The version approved by the CGS and CAC was placed on The Endocrine Society’s web site for comments by members. At each stage of review, the Task Force received written comments and incorporated needed changes.

Conclusions: We recommend against making a diagnosis of androgen deficiency in women at present because of the lack of a well-defined clinical syndrome and normative data on total or free testosterone levels across the lifespan that can be used to define the disorder. Although there is evidence for short-term efficacy of testosterone in selected populations, such as surgically menopausal women, we recommend against the generalized use of testosterone by women because the indications are inadequate and evidence of safety in long-term studies is lacking. A review of the data currently available is presented, and areas of future research are outlined. To formulate clinical guidelines for use of testosterone in women, additional information will be necessary. This includes defining conditions that, when not treated with androgens, have adverse health consequences to women; defining clinical and laboratory parameters that distinguish those with these conditions; and assessing the efficacy and long-term safety of androgen administration on outcomes that are important to women diagnosed with these conditions. This necessary clinical research cannot occur until the biological, physiological, and psychological underpinnings of the role of androgens in women and candidate disorders are further elucidated.

题目：临床实践指南：内分泌学会关于女性雄激素治疗临床实践指南

目的：提供女性雄激素治疗临床实践指南。

参与者：指南制定小组由一名主席（由内分泌学会的临床指南小组委员会挑选产生）、六名专家、一名方法学家和一名擅长医疗文书写作的医疗专家组成。指南制定小组成员未接受任何社会团体的资助和酬劳。

证据：指南制定小组全面回顾了现存的证据以支持其关键的建议。指南制定小组使用统一的语言和图表说明来衡量证据的质量和建议的强度，这一过程中使用建议、评估、研究和评价等级系统方法。建议强度由数字“1”（代表强烈推荐，联合使用词语“我们推荐”）或“2”（代表较弱的推荐，联合使用词语“我们建议”）来表示。证据的质量由交叉填充的圆圈来表示，包括非常低质量的证据、低质量的证据、中等质量的证据和高质量的证据。每一条建议之后紧随着的是对证据的描述。

指南制定程序：经过全面回顾证据、小组会议讨论、数次电话会议和电子邮件讨论后得出指南。在一名擅长医疗文书写作的医疗专家帮助下，指南制定小组提出草稿，随后分别由内分泌学会临床指南小组委员会（CGS）、临床事务委员会（CAS）和执行委员会进行核查。最后由CGS和CAS通过的版本发布在内分泌学会的网站上向所有会员征求意见。在每一阶段的考查过程中，指南制定小组负责写出书面注释并整合一些必要的修改意见。

结论：我们建议反对在当前情况下作出女性雄激素缺乏的诊断，因为缺乏一个定义明确的临床综合征和不同年龄时期总的和游离雄激素水平标准的数据来作为诊断这一病症的依据。尽管有证据表明对部分选择性的人群短期使用睾酮的有效性，如对手术后绝经的妇女，我们仍然建议反对在妇女中普通使用雄激素，因为目前的证据不够充分，且缺乏长期使用的安全性证据。指南中全面回顾了现存的证据，并对未来的一些研究作了简要描述。要明确的叙述女性雄激素临床使用指南还需要更多的信息。包括明确以下一些情况：如为什么不用雄激素治疗及是否对女性的健康存在负作用；明确定义临床和实验室的诊断指标；评估有效性和长期使用的安全性对这类患者女性患者非常重要。只有当女性雄激素的生物学、生理学和心理学作用基础研究发展和病症的机制得到阐明时，才能进行进一步的临床研究。

第50篇翻译
50．Does Coffee Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired Glucose?
咖啡消耗量能否降低糖调节受损个体发生2型糖尿病的风险？

OBJECTIVE—Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low and high blood glucose excursions.

RESEARCH DESIGN AND METHODS—We introduce the average daily risk range (ADRR), a variability measure computed from routine self-monitored blood glucose (SMBG) data. The ADRR was constructed using a development dataset for 39 and 31 adults with type 1 and type 2 diabetes, respectively. The formula was then fixed, and the ADRR was compared against other variability measures using an independent validation dataset containing 4 months of SMBG for 254 and 81 adults with type 1 and type 2 diabetes.

RESULTS—From the 1st month of validation SMBG data, we computed the ADRR, blood glucose SD and coefficient of variation, daily blood glucose range and interquartile range, mean amplitude of glycemic excursion, M-value, and lability index. Then all measures were tested as predictors of low blood glucose (<2.2 mmol/l; <3.9 mmol/l) and high (>10 mmol/l; >22.2 mmol/l) events in the subsequent 3 months. The ADRR was the best predictor of both hypoglycemia and hyperglycemia, with a 6-fold increase in the likelihood of hypoglycemia and 3.5-fold increase in the likelihood of hyperglycemia across its risk categories.

CONCLUSIONS—In a large SMBG database, the ADRR showed strong association with subsequent out-of-control glucose readings. Compared with other variability measures, the ADRR demonstrated a superior balance of sensitivity to predicting both hypoglycemia and hyperglycemia. This prediction was independent from type of diabetes.

目的：最近的一些研究结果发现了控制血糖变异性对减少低血糖和削弱高血糖对心血管和行为并发症风险的重要性。所为设计血糖变异性的测量具有重要的意义，因为其可以同等的预测低和高的漂移。

研究设计和方法：我们引入了平均每日风险范围（ADRR）的概念，一个由常规自我血糖监测（SMBG）数据计算出来的变异性测量参数。ADRR分别从39例1型糖尿病和31例2型糖尿病患者不断更新的资料数据库来建立，固定ADRR的计算公式，然后计算并比较包括0~4个月、254例1型糖尿病患者、81例2型糖尿病患者SMBG资料的ADRR值，这些SMBG资料均经过独立验证。

结果：根据第一个月的SMBG数据，我们计算了ADRR、血糖值标准差（SD）和变异系数、每日血糖值波动范围和四分位间距、血糖漂移的平均幅度、M-值和不稳定指数。在随后的3个月中将所有计算出的参数均作能否预测低血糖(<2.2 mmol/l; <3.9 mmol/l)和高血糖(>10 mmol/l; >22.2 mmol/l)事件的统计学检验。结果发现ADRR同时是低血糖和高血糖的最佳预测因子，与其它风险因素相比，其预测低血糖的可能性增加了6倍，预测高血糖的可能性增加了3.5倍。

结论：通过分析一个大型SMBG数据库结果发现，ADRR值与患者血糖失去控制明显相关。与其它血糖变异性测量参数相比，ADRR值在同时预测低血糖和高血糖事件的灵敏性上的平衡性明显优于其它参数，这种预测价值与糖尿病的类型无关。

2006-12-10 23:15

投票
收藏
打赏
引用
分享
- 微信扫一扫
- 新浪微博
- 丁香客
- 复制网址
举报
- 广告宣传推广
- 政治敏感、违法虚假信息
- 恶意灌水、重复发帖
- 违规侵权、站友争执
- 附件异常、链接失效
- 其他

• 实话实说，非常典型的病例，走过路过，千万…别错过（手术，有结果）

谷子

内分泌科

铁杆站友

+1 积分
127楼

翻译第50篇.
50．Does Coffee Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired Glucose?

OBJECTIVE—The purpose of this study was to investigate the association between coffee intake and incident diabetes based on an oral glucose tolerance test (OGTT) and examine coffee habits in those with impaired glucose separately from those with normal glucose at baseline.

RESEARCH DESIGN AND METHODS—In this prospective study, 910 adults aged 50 years without diabetes at baseline in 1984–1987 were followed to 1992–1996, an average of 8 years after assessment of coffee intake. Logistic regression models were adjusted for sex, age, physical activity, BMI, smoking, alcohol, hypertension, and baseline fasting plasma glucose.

RESULTS—Past and current coffee drinkers had a reduced risk of incident diabetes (odds ratio 0.38 [95% CI 0.17–0.87] and 0.36 [0.19–0.68], respectively) compared with those who never drank coffee. The 317 participants with baseline impaired glucose who were past or current coffee drinkers were also at reduced risk for incident diabetes (0.31 [0.11–0.87] and 0.36 [0.16–0.83], respectively).

CONCLUSIONS—This study confirms a striking protective effect of caffeinated coffee against incident diabetes and extends these findings to incident diabetes based on OGTT independent of multiple plausible confounders.

题目：咖啡消耗量能否降低糖调节受损个体发生2型糖尿病的风险？

目的：调查咖啡摄入量与OGTT诊断的偶发糖尿病之间的联系，同时将基线时的糖调节受损人群与正常血糖人群分组分别调查其饮用咖啡的习惯。

研究设计和方法：在本前瞻性研究中，910名年龄 50岁、基线时（1984–1987）未患糖尿病的成年人在1992–1996之间接受了随访，鉴定咖啡摄入量后平均随访了8年。使用Logistic回归模型来分析数据，分别调整性别、年龄、体力活动、BMI、吸烟、饮酒、高血压和基线时的空腹血糖值来进行分析。

结果：过去曾经饮用过咖啡和现在仍饮用咖啡的人发生糖尿病的风险较从未饮用过咖啡的人下降，优势比分别为0.38 [95%置信区间 0.17–0.87] 和0.36[95%置信区间0.19–0.68]。317名过去曾经饮用过咖啡和现在仍饮用咖啡且基线时是糖调节受损的参与者发生糖尿病的风险下降，优势比分别为0.31 [95%置信区间 0.11–0.87] 和0.36[95%置信区间0.16–0.83]。

结论：本研究证实了咖啡因对糖尿病的发生具有显著的保护效应。此结论可以扩展到针对OGTT诊断的偶发糖尿病，且不依赖于多种看起来似乎合理的混杂因素。

2006-12-11 17:19

投票
收藏
打赏
引用
分享
- 微信扫一扫
- 新浪微博
- 丁香客
- 复制网址
举报
- 广告宣传推广
- 政治敏感、违法虚假信息
- 恶意灌水、重复发帖
- 违规侵权、站友争执
- 附件异常、链接失效
- 其他

• （原创）血钠183mmol/L的老年人急救处理？

内分泌

☆☆欢迎参加内分泌期刊文摘翻译第7期☆☆

提示

丁香园旗下网站

关于丁香园

官方链接

内分泌

分享到：

微信扫一扫

☆☆欢迎参加内分泌期刊文摘翻译第7期☆☆

微信扫一扫

微信扫一扫

微信扫一扫

微信扫一扫

提示

丁香园旗下网站

关于丁香园

官方链接