外网1月7日电日本国立癌症研究中心7日宣布，患宫颈癌的产妇在生产时，癌细胞转移给了腹内婴儿，已发现两名男性婴儿确诊肺癌。此类病历为全球首次确认。相关研究成果已登载在美国医学杂志《新英格兰医学杂志》上。

浅薄如我，觉得今天可能是愚人节

元芳，你怎么看？

N Engl J Med 2021; 384:42-50

DOI: 10.1056/NEJMoa2030391

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants

Summary

Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141