All 15 cases of retroperitoneal schwannoma were solitary, 12 cases were located in the paraspinal area of abdominal retroperitoneum, of which 10 cases were located between the spinal column and kidney, in front of psoas major muscle, 3 cases were located in the pelvic retroperitoneum, of which 2 cases were located in the anterior sacral space, and the other case was located in the area of right sciatic nerve. Ultrasonography showed there were 3 schwannomas displaying as solid tumors, 9 as cystic and solid ones, and 3 as cystic ones. Ultrasonic features of most retroperitoneal schwannomas in this study were as follows: regular morphology (86.7%), clear boundary (93.3%), internal cystic degeneration (80%), poor blood flow signal (66.7%), no calcification (86.7%), no target sign (93.3%) and no detected affected nerve (93.3%). Compared with superficial schwannoma, retroperitoneal schwannomas have larger tumor volume, more common internal cystic degeneration and poor blood flow signal, but target signs and affected nerves were less common (P<0.05). Retroperitoneal schwannomas have different ultrasonic features from superficial schwannomas.