SChLAP1-HNRNPL复合物促进RelA入核，导致脑胶质瘤恶性增殖

Long noncoding RNA SChLAP1 forms a growth promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-κB signaling

DOI: 10.1158/1078-0432.CCR-19-0747

https://clincancerres.aacrjournals.org/content/early/2019/09/06/1078-0432.CCR-19-0747

SChLAP1-HNRNPL复合物能通过抑制ACTN4的泛素化途径降解，进而激活NF-κB通路，促进关键转录因子RelA入核，最终导致肿瘤的恶性增殖。