(a)Can cycle open and close rapidly causing seizures.
(b)Nav1.2 is expressed in sensory neurons.
(c)Mutations may cause long QT syndrome.
(d)Have no role in acute pain.
(e)Phenytoin blocks both fast current and persistent current channels.
45.T F T T T
Sensory neurons express Na1.2, Na1.8 and Na1.9. Na1.7 is in peripheral nervous system along with Na1.4 and Na1.5 in muscles. Mutations in Na 1.5 cause long QT syndrome, while mutations in Na1.4 cause hypercalcaemic periodic paralysis. Persistent sodium current is a small fraction of the fast current and has a role in regulating excitability.
(c)Anandamide causes inhibition of adenyl cyclase to cause effect.
(d)Anandamide is degraded by fatty acid amide hydrolase (FAAH).
(e)2-AG is a full agonist at CB1 receptors.
53.F F F T T
The other members of the family are 2-arachidonoylglycerol, noladin ether and virodhamine. The synthesis is in neurons apart from basophils, macrophages and microglia. Anandamide also causes inhibition of N-P/Q and L-type voltage-gated calcium channels. Ibuprofen and ketorolac inhibit FAAH.