Sodium channels:

(a)Can cycle open and close rapidly causing seizures.

(b)Nav1.2 is expressed in sensory neurons.

(c)Mutations may cause long QT syndrome.

(d)Have no role in acute pain.

(e)Phenytoin blocks both fast current and persistent current channels.

45.T F T T T

Sensory neurons express Na1.2, Na1.8 and Na1.9. Na1.7 is in peripheral nervous system along with Na1.4 and Na1.5 in muscles. Mutations in Na 1.5 cause long QT syndrome, while mutations in Na1.4 cause hypercalcaemic periodic paralysis. Persistent sodium current is a small fraction of the fast current and has a role in regulating excitability.

感觉b对的，而D是错的

我认为你是对的

Nav1.7在急性疼痛中起重要作用——Nassar MA, et al. (2004) PNAS. 101:12706-11.