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【原创】2014年以来Journal of Virology植物病毒相关文献汇总（6.16更新）

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这个帖子发布于7年零24天前，其中的信息可能已发生改变或有所发展。

虽然影响因子只是在5，6之间。但 Journal of virology公认为病毒方向的顶尖杂志。自己是植物病毒方向，跟踪下2014年以来的植物病毒相关文献，和大家一起分享。
细翻下这个杂志，会发现其中植物病毒相关的文章少的可怜，从2014年开始，到目前为之有4期在线发表。

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更新至16.6.2014

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2014-02-11 18:15 浏览 : 8254 回复 : 13

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donggua 编辑于 2014-06-16 20:04

• 2021.02+中医药单用／联合抗生素治疗社区获得性肺炎临床实践指南

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1，

Tatineni, S., Kovacs, F., and French, R. 2014. Wheat streak mosaic virus Infects Systemically despite Extensive Coat Protein Deletions: Identification of Virion Assembly and Cell-to-Cell Movement Determinants. J. Virol. 88:1366–1380.
发表在一月份的一篇关于小麦条带花叶病毒的文章。
Wheat streak mosaic virus Infects Systemically despite Extensive Coat Protein Deletions: Identification of Virion Assembly and Cell-to-Cell Movement Determinants
摘要
Viral coat proteins function in virion assembly and virus biology in a tightly coordinated manner with a role for virtually every amino acid. In this study, we demonstrated that the coat protein (CP) of Wheat streak mosaic virus (WSMV; genus Tritimovirus, family Potyviridae) is unusually tolerant of extensive deletions, with continued virion assembly and/or systemic infection found after extensive deletions are made. A series of deletion and point mutations was created in the CP cistron of wild-type and/or green fluorescent protein-tagged WSMV, and the effects of these mutations on cell-to-cell and systemic transport and virion assembly of WSMV were examined. Mutants with overlapping deletions comprising N-terminal amino acids 6 to 27, 36 to 84, 85 to 100, 48 to 100, and 36 to 100 or the C-terminal 14 or 17 amino acids systemically infected wheat with different efficiencies. However, mutation of conserved amino acids in the core domain, which may be involved in a salt bridge, abolished virion assembly and cell-to-cell movement. N-terminal amino acids 6 to 27 and 85 to 100 are required for efficient virion assembly and cell-to-cell movement, while the C-terminal 65 amino acids are dispensable for virion assembly but are required for cell-to-cell movement, suggesting that the C terminus of CP functions as a dedicated cell-to-cell movement determinant. In contrast, amino acids 36 to 84 are expendable, with their deletion causing no obvious effects on systemic infection or virion assembly. In total, 152 amino acids (amino acids 6 to 27 and 36 to 100 and the 65 amino acids at the C-terminal end) of 349 amino acids of CP are dispensable for systemic infection and/or virion assembly, which is rare for multifunctional viral CPs.
病毒的衣壳蛋白一般在病毒粒子包装时具有重要作用，而该研究的结果表明，小麦条带花叶病毒的衣壳蛋白对突变缺失等具有很强的耐受性。有兴趣的可以细看全文。

全文：
http://jvi.asm.org/content/88/2/1366.full

Tatineni et al. - 2014 - Wheat streak mosaic virus Infects Systemically des.pdf(3487.05k)

2014-02-11 18:21

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donggua 编辑于 2014-02-12 19:48

• （原创）低血糖、低血钠、多尿，高尿糖、酮体阳性？

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2，发表在3月份的一篇关于烟草花叶病毒的文章
The Tobacco mosaic virus Movement Protein Associates with but Does Not Integrate into Biological Membranes
摘要
Plant positive-strand RNA viruses require association with plant cell endomembranes for viral translation and replication, as well as for intra- and intercellular movement of the viral progeny. The membrane association and RNA binding of the Tobacco mosaic virus (TMV) movement protein (MP) are vital for orchestrating the macromolecular network required for virus movement. A previously proposed topological model suggests that TMV MP is an integral membrane protein with two putative α-helical transmembrane (TM) segments. Here we tested this model using an experimental system that measured the efficiency with which natural polypeptide segments were inserted into the ER membrane under conditions approximating the in vivo situation, as well as in planta. Our results demonstrated that the two hydrophobic regions (HRs) of TMV MP do not span biological membranes. We further found that mutations to alter the hydrophobicity of the first HR modified membrane association and precluded virus movement. We propose a topological model in which the TMV MP HRs intimately associate with the cellular membranes, allowing maximum exposure of the hydrophilic domains of the MP to the cytoplasmic cellular components.
IMPORTANCE To facilitate plant viral infection and spread, viruses encode one or more movement proteins (MPs) that interact with ER membranes. The present work investigated the membrane association of the 30K MP of Tobacco mosaic virus (TMV), and the results challenge the previous topological model, which predicted that the TMV MP behaves as an integral membrane protein. The current data provide greatly needed clarification of the topological model and provide substantial evidence that TMV MP is membrane associated only at the cytoplasmic face of the membrane and that neither of its domains is integrated into the membrane or translocated into the lumen. Understanding the topology of MPs in the ER is vital for understanding the role of the ER in plant virus transport and for predicting interactions with host factors that mediate resistance to plant viruses.
烟草花叶病毒的运动蛋白mp上拥有两个疏水区域，与结合膜有关，但并不跨过膜。作者认为运动蛋白的两个疏水域与细胞膜密切相关，能够使其亲水域最大暴露在细胞质中。
全文：
http://jvi.asm.org/content/88/5/3016.full

Peiro? et al. - 2014 - The Tobacco mosaic virus Movement Protein Associat.pdf(1823.56k)

2014-02-11 18:32

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donggua 编辑于 2014-02-12 19:49

• 💰「有奖悬赏」2021考研调剂的娃看过来！

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几篇刚接受的文献
3，
Relocation of the NIb gene in the tobacco etch potyvirus genome
摘要
Potyviruses express most of their proteins from a long open reading frame that is translated into a large polyprotein processed by three viral proteases. To understand the constraints on potyvirus genome organization, we relocated the viral RNA-dependent RNA polymerase (NIb) cistron to all possible intercistronic positions of the Tobacco etch virus (TEV) polyprotein. Only viruses with NIb at the amino terminus of the polyprotein or in between P1 and HC-Pro were viable in tobacco plants.
全文：http://jvi.asm.org/content/early/2014/01/16/JVI.03336-13.full.pdf+html

2014-02-11 19:07

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• 三脑室占位，MR平扫+增强，有病理结果（一周后公布病理）

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【原创】2014年以来Journal of Virology植物病毒相关文献汇总（6.16更新）

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