【专题讨论】Notch信号大家谈

把最近的Seminar in cancer biology 里面Notch专辑作了全部编译，共8个 主要是和癌症相关的，欢迎大家来拍 啊！(b)

1、Notch signaling in development and disease
疾病和发育中的Notch信号


Emil M. Hansson, Urban Lendahl∗, Gavin Chapman
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm SE-171 77, Sweden
Abstract
Cells in multicellular organisms need to decipher extracellular cues into appropriate responses including correct differentiation choices. A considerable portion of this information is relayed through a surprisingly small number of signaling pathways, which are highly evolutionarily conserved and used in many different cell types. This “ivy league” of signaling mechanisms comprises the Wnt/wingless, BMP/TGF-beta, Sonic Hedgehog, receptor tyrosine kinases, nuclear receptors, JAK/STAT and, the subject of this review, the Notch signaling pathway. The aim of this article is to provide an overview of the Notch signaling pathway. The role of Notch in various types of cancers is discussed in the accompanying articles in this issue of SCBI.
© 2004 Elsevier Ltd. All rights reserved.
Keywords: Cell–cell communication; Endocytosis; CSL; Numb; BMP

多细胞生物必需对外界的信号作出适当的反应，比如说细胞对其分化的选择。大部分这种信息的传递都是通过一种在进化上保守的细胞小分子来完成的。这一类“常春藤联盟”（老美的比喻而已，“核心集团”）包括Wnt/wingless, BMP/TGF-beta, Hedgehog,受体酪氨酸激酶, 核受体, JAK/STAT 信号通路以及我们将要展开论述的Notch信号通路。这篇文章对Notch信号通路作了概括，而其在各种癌症中的作用将在以下的文章进行具体讨论，这篇文章不再做进一步展开。

主要包括：
1、简述Notch通路的研究史
2、具体化Notch信号通路
3、Notch相作用或相修饰的蛋白
4、Notch与其他信号通路的“对话”
5、Notch信号通路与疾病的关系
6、Notch信号通路和癌症的关系









对首次接触这条通路的新手来说是份不错的参考资料。