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In this study the authors evaluated performance of the tumor marker panel including CEA, CYFRA21-1, SCC, NSE, ProGRP and CA125 in the histological diagnosis of lung cancer.

4. Large Cell Neuroendocrine Carcinoma is no longer classified as a variant of Large Cell Carcinoma. According to the new 2015 WHO classification (J Thorac Oncol. 2015;10: 1243–1260) all lung tumors with neuroendocrine differentiation should be grouped together into one category – neuroendocrine tumors, including those of high grade SCLC and LCNEC, while the diagnosis of large cell carcinoma should be restricted only to small group of resected tumors that lack any clear morphologic or immunohistochemical differentiation with reclassification of the remaining former large cell carcinoma subtypes into different categories. Since recent data indicate that chemotherapy regimens used for SCLC may be a better option for LCNEC (NCCN guidelines 2017, SCLC), discrimination of LCNEC from NSCLC has become more relevant. 

我们是按照2001年WHO的肺癌分类标准，收集2014年-2015年病例，而审稿人提出了2015年新标准（Large Cell Carcinoma）。