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西班牙全脸移植成功全球首宗缔造历史--附:国内外"颜面(全脸或部分)复合组织异体移植"研究最新进展中英文献! [精华]

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这个帖子发布于10年零316天前，其中的信息可能已发生改变或有所发展。

(图文)西班牙全脸移植成功全球首宗缔造历史(注:本贴内附:国内外"颜面复合组织异体移植"研究最新进展中英专业文献!)

(Vall d’Hebron University Hospital)廿二日宣布，在叁月廿日完成世界首例全脸移植手术，病患是一名卅多岁的农夫，他在五年前意外**轰垮自己脸部，导致长期无法正常唿吸、吞嚥并说话。

　　西班牙一名卅余岁男子因*伤失去鼻子、上颔等，医师为他移植来自捐赠者的脸部皮肤、肌肉、鼻子、颔骨、牙齿和颧骨等组织和器官。图为电脑模拟的移植前后伤患相貌。
　　24小时马拉松手术
　　由卅名专家组成的西班牙医疗团队，这次进行长达廿四小时的马拉松式全脸移植手术，藉着一名匿名脑死捐赠者的脸部组织，为一名未透露姓名的男性病患更新并重建脸部皮肤、肌肉、牙齿、鼻子、嘴唇和颧骨和下颚等，几乎除了眼球和舌头之外，整个脸部全部换新。
　　主持全脸变换手术的***医师(JoanPere Barret)表示，这次手术相当成功，目前病患在医院復塬情况良好，并未发生组织排斥或感染的现象。他说，这位病患的新面貌，不论和捐赠者或他本人在事故发生前的样子，统统都不像，「他现在有一张全新的脸。」
　　病患拥有全新面貌
　　这名病患约卅多岁，五年前他意外**打中自己的脸部，失去鼻子和下颚，不仅严重毁容，还须靠插管帮助唿吸和补充营养。如今「变脸」手术成功，预料几周后，他便可正常「说话、饮食和微笑、大笑」。
　　***医师又说：「他在手术前无法说话，在服用类固醇和其他药物后，预计下周他便可吞嚥食物。」

中国日报 2010-04-24 21:00:19

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下面相同消息(英文)内容来源 A P, B B C.

World's First Full Face Transplant A Success Say Spanish Doctors

Article Date: 26 Apr 2010 - 2:00 PDT

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Spanish doctors who carried out a full face transplant on a man who injured himself in a shooting accident five years ago that left him unable to breathe or swallow, said the operation, the first of its kind in the world, has been a success.

The 30-doctor team at Vall d'Hebron University Hospital in Barcelona operated for over 20 hours to transplant a completely new face from the donor to the recipient, a young farmer who accidentally shot himself in the face in 2005.

The recipient, who now has new facial skin and muscles, jaw, cheekbones, nose, lips, teeth, and eyelids, underwent the transplant in March, but news of the transplant has only been announced in the last few days. The patient is said to be recovering well.

Although worldwide there have been 10 partial face transplants, this is the first complete one, and the most complex, according to the hospital.
Speaking for the hospital, Bianca Bolt told the *** that this was the "first to transplant all of the face and some bones of the face".

The procedure started with a four hour operation to remove the face from the dead donor. This removed veins, arteries, skin, muscles and bone. Part way through this procedure they anesthetized the recipient and removed skin grafts from his face.

The final stage was then to transplant the donor face and blood vessels onto the recipient, in one piece, using microvascular surgery to stitch the blood vessels precisely in place.

Dr Joan Pere Barret, who headed the transplant team, said they transplanted the face like a mask onto the patient, who now has a completely new face from his hairline to his neck. You can only see one scar, like a wrinkle across his neck, said Barret, adding that the patient is able to walk around his room and watch television.

No details of the donor have been released, except Barret said they were of similar weight, height, facial proportions and skin tone as the recipient.

Experts worldwide have praised the surgery, which was carried out on 20 March.

Dr Thomas Romo, chief of facial and reconstructive surgery at Lenox Hill Hospital in New York, told Associated Press that:

"It is a breakthrough. They are pushing the envelope and I am very happy for them."

British experts agree this is probably the most complex face transplant yet, as it appears to include more bone and more of the lower face.

A spokesperson for the UK's Facial Transplantation Research Team told the *** it was "a tremendous achievement", and shows how such operations can help the few most severely injured people for whom facial reconstruction either isn't feasible or hasn't worked.

The Spanish patient, who has not been named, shot himself in the face by accident with a shotgun in 2005, destroying his face from the eye sockets downwards, without damaging his eyes and eyesight.

Before the transplant he underwent nine operations, was unable to speak properly, was only able to breathe with a ventilator and take food through a tube.

Barret said he still can't eat, speak or smile, reported the Associated Press, but he can see and swallow saliva. Doctors expect him to be able to eat and breathe on his own in the next few days.

Sources: AP, B B C.

Written by: Catharine Paddock, PhD

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2010-04-25 17:54 浏览 : 6631 回复 : 63

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huabin 编辑于 2010-05-09 20:44

• 2020年西综254分-现在不算晚（之前的手机号登不上去了）

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本人对"异体颜面移植术(其专业术语称"颜面部复合组织异体移植术")的初步看法如下:

其一.异体颜面移植远较实质器官移植问题复杂的多,因其除涉及到动静脉血管重建之外,还有面部相应骨头与神经重建等等问题!而器官移植则不涉及后者等等问题!

其二.异体颜面移植因涉及到机体复合多种组织重建,非机体单一性质组织移植问题可比!个人认为:或许该术移植后的急性排斥反应更为剧烈,与此有关!

其三.异体颜面移植涉及到人类日常重要的下列功能活动:例如吃与吞咽,说话,自由呼吸与看与笑等功能活动!而器官移植则也不涉及这些困难的功能恢复问题!

其四.异体颜面移植还涉及到口腔黏膜与脸部皮肤的感觉功能恢复问题!尽管在救命的前提下这些可以略去不管,但修复重建为目的时就不得不考虑这些功能!

诸上种种情况说明:个人认为异体颜面移植术其之困难程度,或许仅次于人类最后尚待攻克的"脑移植术"!

D.QU

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下转本站商隐医师的解剖一贴!以供对图思考该术!看看这些与"异体颜面移植术"相关之局解图,或许您就会同意本人对该术的上述看法!