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【科普】叶酸降低脑卒中风险

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Study: Folic Acid Cuts Stroke Risk

To conduct the study, professor Xiaobin Wang, of Children's Memorial Hospital and Children's Memorial Research Center at Northwestern University Feinberg School of Medicine in Chicago, and his colleagues analyzed the data from eight trials involving the use of folic acid and its effect on strokes.

They concluded that folic acid lowers the concentrations homocysteine in the blood. High amounts of homocysteine have been linked to the increased risk of stroke, cardiovascular disease and deep vein thrombosis.

Despite the link between homocysteine and other cardiovascular diseases, researchers were unable to determine whether folic acid would cut the risk for diseases other than stroke.

They were able to conclude that the use of folic acid supplements reduced the risk of stroke by an average of 18 percent. In subgroup analyses, an even greater reduction of risk was seen when the treatment lasted over 36 months, which resulted in a 29 percent reduced risk.

Researchers also found that if folic acid was able to cut the concentration of homocysteine in the blood by more than 20 percent, the risk was reduced by 23 percent and, if the patient had no previous history of stroke, the risk was cut by 23 percent.

The study also found that in areas of the country that did not already have supplementation through fortified or partly fortified grain, folic acid supplementation decreased the risk of stroke by 25 percent.

The authors said future studies were needed to test the efficacy of folic acid and that clinical trials should be done over longer periods of times — four years or more; in regions without grain fortification; and on individuals that have a history of stroke.

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2007-06-03 11:45 浏览 : 1155 回复 : 2

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freelane 编辑于 2007-06-03 18:22

• 死亡患者危重讨论怎么写？

junfan

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本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。

2007-06-03 12:35

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• 一图解读｜血常规化验单

junfan

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Study: Folic Acid Cuts Stroke Risk
研究:叶酸降低脑卒中风险

To conduct the study, professor Xiaobin Wang, of Children's Memorial Hospital and Children's Memorial Research Center at Northwestern University Feinberg School of Medicine in Chicago, and his colleagues analyzed the data from eight trials involving the use of folic acid and its effect on strokes.
为了进行这项研究，芝加哥西北大学feinberg医学院儿童纪念医院及儿童纪念研究中心的王晓斌教授及其同事对涉及使用叶酸及其对卒中的影响的8项试验的数据进行了分析。

They concluded that folic acid lowers the concentrations homocysteine in the blood. High amounts of homocysteine have been linked to the increased risk of stroke, cardiovascular disease and deep vein thrombosis.
他们的结论是：叶酸可降低血液中同型半胱氨酸的浓度。（而以往的研究显示）高浓度的同型半胱氨酸与卒中危险的增加、心血管疾病和深静脉血栓形成有关联。

Despite the link between homocysteine and other cardiovascular diseases, researchers were unable to determine whether folic acid would cut the risk for diseases other than stroke.
尽管已有研究显示同型半胱氨酸与其他心血管疾病之间存在关联，研究人员还没能确定叶酸能否降低除卒中以外的其它疾病的风险。

They were able to conclude that the use of folic acid supplements reduced the risk of stroke by an average of 18 percent. In subgroup analyses, an even greater reduction of risk was seen when the treatment lasted over 36 months, which resulted in a 29 percent reduced risk.
他们能够断定使用叶酸补充剂能将卒中风险平均降低 18 % 。在分组讨论分析中，他们观察到了进一步的风险降低，即当治疗时间超过36个月时，卒中风险可降低29 % 。

Researchers also found that if folic acid was able to cut the concentration of homocysteine in the blood by more than 20 percent, the risk was reduced by 23 percent and, if the patient had no previous history of stroke, the risk was cut by 23 percent.
研究人员还发现，如果叶酸能将血液中同型半胱氨酸的浓度降低超过20 %，则卒中风险就能降低23 % ；而如果病人没有卒中前史，卒中风险将减少23 % 。

The study also found that in areas of the country that did not already have supplementation through fortified or partly fortified grain, folic acid supplementation decreased the risk of stroke by 25 percent.
这项研究还发现：在该国没有推行强化谷物或部分强化谷物作为补充剂的许多地区中，叶酸补充剂可将卒中风险降低25 % 。

The authors said future studies were needed to test the efficacy of folic acid and that clinical trials should be done over longer periods of times — four years or more; in regions without grain fortification; and on individuals that have a history of stroke.
作者说,将来还需要开展研究以测试叶酸此种功效，同时应该在未推行强化谷物的地区，对已患过卒中的个体开展长时间--四年或四年以上--的临床试验。

编译：

研究显示叶酸降低脑卒中风险

为了评估叶酸对脑卒中风险的影响，芝加哥西北大学feinberg医学院儿童纪念医院及儿童纪念研究中心的王晓斌教授及其同事对涉及使用叶酸及其对卒中的影响的8项试验的数据进行了分析。他们的结论是：叶酸可降低血液中同型半胱氨酸的浓度。而以往的研究显示高浓度的同型半胱氨酸与卒中危险的增加、心血管疾病和深静脉血栓形成有关联。

尽管已有研究显示同型半胱氨酸与其他心血管疾病之间存在关联，研究人员还是没能确定叶酸能否降低除卒中以外的其它疾病的风险。他们能够断定的是使用叶酸补充剂能将卒中风险平均降低 18 % 。在分组讨论分析中，他们观察到了进一步的风险降低，即当治疗时间超过36个月时，卒中风险可降低29 % 。他们还发现，如果叶酸能将血液中同型半胱氨酸的浓度降低超过20 %，则卒中风险就能降低23 % ；而如果病人没有卒中前史，卒中风险将减少23 % 。而在该国没有推行强化谷物或部分强化谷物作为补充剂的许多地区中，叶酸补充剂可将卒中风险降低25 % 。

作者声称将来还需要开展研究以测试叶酸此种功效，同时应该在未推行强化谷物的地区，对已患过卒中的个体开展长时间--四年或四年以上--的临床试验。

2007-06-03 13:37

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junfan 编辑于 2007-06-03 13:43

• 快问快答：为什么哮喘控制维持至少3个月才可考虑降级治疗

pharmaqxh

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该文章在Faculty of 1000 medicien的评分为6（must read），我可以提供该文章的全文和翻译稿，不知大家可有用。
如需要，请通知。

2007-06-22 07:13

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pharmaqxh 编辑于 2007-06-22 07:18

• 科技部通报李红良、饶毅教授、曹雪涛院士等有关论文涉嫌造假处理情况

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