【medical-news】糖尿病增加肾结石风险
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Diabetes Linked to Upswing in Kidney Stones
NEW YORK (Reuters Health) Jan 30 - Recent studies suggest that the incidence of nephrolithiasis is increasing, both in the US and worldwide, and data compiled by researchers at the Mayo Clinic in Rochester, Minnesota, suggest that diabetes may be a predisposing factor for renal stones, particularly for those composed of uric acid.
Dr. John C. Lieske and his associates used the Rochester Epidemiology Project diagnostic index to identify all Olmsted County residents diagnosed with nephrolithiasis between 1980 and 1999. The 3,561 cases were matched by age and gender with an equal number of control subjects. They then searched the index for diagnoses of diabetes, hypertension, and obesity.
After adjusting for age, calendar year of index, hypertension, and obesity, diabetes was significantly associated with a diagnosis of nephrolithiasis (odds ratio 1.22, p = 0.02), the team reports in the American Journal of Kidney Disease for December.
For closer scrutiny of this issue, Dr. Lieske's group obtained a random sample of 269 subjects with confirmed incident nephrolithiasis and their 260 matched stone-free controls. The odds ratio for diabetes was of a similar magnitude but was no longer statistically significant due to the smaller sample size.
However, when they analyzed the cases according to stone type, the prevalence of diabetes was 40% among the 10 individuals with uric acid stones, versus 9% among the 112 with calcium stones and 7% in the control group. After adjusting for BMI, the odds ratio for diabetes associated with uric acid stones was 5.03 (p = 0.03).
Even so, the investigators say it's unlikely that diabetes is the only factor driving the increased incidence of nephrolithiasis. It may be partly attributed to "better detection, because of widespread use of sensitive imaging modalities."
Am J Kidney Dis 2006;48:897-904.
http://www.medscape.com/viewarticle/551481
NEW YORK (Reuters Health) Jan 30 - Recent studies suggest that the incidence of nephrolithiasis is increasing, both in the US and worldwide, and data compiled by researchers at the Mayo Clinic in Rochester, Minnesota, suggest that diabetes may be a predisposing factor for renal stones, particularly for those composed of uric acid.
Dr. John C. Lieske and his associates used the Rochester Epidemiology Project diagnostic index to identify all Olmsted County residents diagnosed with nephrolithiasis between 1980 and 1999. The 3,561 cases were matched by age and gender with an equal number of control subjects. They then searched the index for diagnoses of diabetes, hypertension, and obesity.
After adjusting for age, calendar year of index, hypertension, and obesity, diabetes was significantly associated with a diagnosis of nephrolithiasis (odds ratio 1.22, p = 0.02), the team reports in the American Journal of Kidney Disease for December.
For closer scrutiny of this issue, Dr. Lieske's group obtained a random sample of 269 subjects with confirmed incident nephrolithiasis and their 260 matched stone-free controls. The odds ratio for diabetes was of a similar magnitude but was no longer statistically significant due to the smaller sample size.
However, when they analyzed the cases according to stone type, the prevalence of diabetes was 40% among the 10 individuals with uric acid stones, versus 9% among the 112 with calcium stones and 7% in the control group. After adjusting for BMI, the odds ratio for diabetes associated with uric acid stones was 5.03 (p = 0.03).
Even so, the investigators say it's unlikely that diabetes is the only factor driving the increased incidence of nephrolithiasis. It may be partly attributed to "better detection, because of widespread use of sensitive imaging modalities."
Am J Kidney Dis 2006;48:897-904.
http://www.medscape.com/viewarticle/551481
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