【medical-news】舒张性心力衰竭患者普遍存在心脏运动不同步
发布于 2007-01-26 · 浏览 1505 · IP 浙江浙江
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Dyssynchrony Common in Diastolic Heart Failure
NEW YORK (Reuters Health) Jan 25 - Both systolic and diastolic dyssynchrony occur frequently in patients with diastolic heart failure, according to a study conducted at The Methodist Hospital in Houston.
Treatment of dyssynchrony shortens the diastolic intraventricular time delay and improves left ventricular relaxation, Dr. Sherif F. Nagueh and his associates report in the Journal of the American College of Cardiology for January 2/9.
There has been little examination of the prevalence or effects of dyssynchrony in patients with diastolic heart failure and normal ejection fraction, the authors note, and there are no published data on the effects of therapy on dyssynchrony.
They therefor conducted hemodynamic and echocardiographic studies on three groups of patients matched by age and gender: 60 patients with diastolic heart failure and ejection fraction of 50% or higher, 60 patients with systolic heart failure with ejection fraction of less than 50%, and 35 controls.
Systolic dyssynchrony was present in 33% of patients with diastolic heart failure and 40% of those with systolic heart failure.
In contrast, diastolic dyssynchrony was present in 58% of those with diastolic heart failure and in 60% of those with systolic heart failure.
Compared with controls, the patients had higher left ventricular mass, left atrial volume index, and pulmonary artery systolic pressure. Tissue Doppler also showed longer systolic and diastolic intraventricular delays in the heart failure patients.
Medications, including diuretics, beta-blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors, and/or angiotensin-receptor blockers, decreased blood pressure and left ventricular filling pressures and improved left ventricular relaxation. However, ejection fraction and left atrial volume index stayed the same.
Biventricular pacing is beneficial in patients with systolic heart failure, but it is unknown how it would affect patients with diastolic heart failure, the researchers point out.
"However," they conclude, "it may be beneficial, similar to the observations in those with depressed ejection fraction, to some but not all patients, given the multiple etiologies of diastolic dyssynchrony in patients with diastolic heart failure."
J Am Coll Cardiol 2007;49:88-96.
http://www.medscape.com/viewarticle/551294
NEW YORK (Reuters Health) Jan 25 - Both systolic and diastolic dyssynchrony occur frequently in patients with diastolic heart failure, according to a study conducted at The Methodist Hospital in Houston.
Treatment of dyssynchrony shortens the diastolic intraventricular time delay and improves left ventricular relaxation, Dr. Sherif F. Nagueh and his associates report in the Journal of the American College of Cardiology for January 2/9.
There has been little examination of the prevalence or effects of dyssynchrony in patients with diastolic heart failure and normal ejection fraction, the authors note, and there are no published data on the effects of therapy on dyssynchrony.
They therefor conducted hemodynamic and echocardiographic studies on three groups of patients matched by age and gender: 60 patients with diastolic heart failure and ejection fraction of 50% or higher, 60 patients with systolic heart failure with ejection fraction of less than 50%, and 35 controls.
Systolic dyssynchrony was present in 33% of patients with diastolic heart failure and 40% of those with systolic heart failure.
In contrast, diastolic dyssynchrony was present in 58% of those with diastolic heart failure and in 60% of those with systolic heart failure.
Compared with controls, the patients had higher left ventricular mass, left atrial volume index, and pulmonary artery systolic pressure. Tissue Doppler also showed longer systolic and diastolic intraventricular delays in the heart failure patients.
Medications, including diuretics, beta-blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors, and/or angiotensin-receptor blockers, decreased blood pressure and left ventricular filling pressures and improved left ventricular relaxation. However, ejection fraction and left atrial volume index stayed the same.
Biventricular pacing is beneficial in patients with systolic heart failure, but it is unknown how it would affect patients with diastolic heart failure, the researchers point out.
"However," they conclude, "it may be beneficial, similar to the observations in those with depressed ejection fraction, to some but not all patients, given the multiple etiologies of diastolic dyssynchrony in patients with diastolic heart failure."
J Am Coll Cardiol 2007;49:88-96.
http://www.medscape.com/viewarticle/551294
最后编辑于 2022-10-09 · 浏览 1505
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