【medical-news】多伦多医院的研究人员取得有望治愈糖尿病的重要发现
发布于 2006-12-22 · 浏览 564 · IP 上海上海
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RESEARCHERS AT A TORONTO HOSPITAL MAKE A SIGNIFICANT FIND FOR POSSIBLE DIABETES CURE
DATE: December 15, 2006
A Canadian-led research team has uncovered the trigger for Type 1 diabetes, a "breakthrough" that allowed them to cure the disease in mice and could ease the suffering of millions worldwide. "This discovery, a breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression," the scientists said in a statement.
The findings by researchers at Toronto's Hospital for Sick Children, the University of Calgary and the Jackson Laboratory in Maine were published in the December 15 issue of the journal Cell. Type 1 diabetes is an autoimmune disorder that affects millions of people worldwide, about 10 percent of all diabetes cases. It arises when certain cells responsible for insulin production become inflamed and are ultimately destroyed, making it impossible for the body to produce insulin. Insulin deficiency is fatal and current insulin replacement therapies cannot prevent many side effects such as heart attacks, blindness, strokes, loss of limbs and kidney function. Most studies on Type 1 diabetes had focused on the immune system, but the Canadian-led team found a link between the disease and the nervous system.
The group discovered that abnormal nerve endings in insulin-producing pancreas islet cells sparked a chain of events that caused Type 1 diabetes in mice. When they removed the sensory neurons, it prevented inflammation of the cells and the mice did not develop the disorder. An injection also cleared islet cell inflammation in afflicted mice within a day and normalized the elevated insulin resistance normally associated with the disease. "We have created a better understanding of both Type 1 and Type 2 diabetes, with new therapeutic targets and approaches derived for both diseases," said study collaborator Pere Santamaria of the University of Calgary. "We are now working hard to extend our studies to patients, where many have sensory nerve abnormalities, but we don't yet know if these abnormalities start early in life and if they contribute to disease development." The treatment is now being tested for Type 2 or obesity-related diabetes, in which insulin resistance is even more severe, with "strong evidence" so far it will work, the researchers said.
DATE: December 15, 2006
A Canadian-led research team has uncovered the trigger for Type 1 diabetes, a "breakthrough" that allowed them to cure the disease in mice and could ease the suffering of millions worldwide. "This discovery, a breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression," the scientists said in a statement.
The findings by researchers at Toronto's Hospital for Sick Children, the University of Calgary and the Jackson Laboratory in Maine were published in the December 15 issue of the journal Cell. Type 1 diabetes is an autoimmune disorder that affects millions of people worldwide, about 10 percent of all diabetes cases. It arises when certain cells responsible for insulin production become inflamed and are ultimately destroyed, making it impossible for the body to produce insulin. Insulin deficiency is fatal and current insulin replacement therapies cannot prevent many side effects such as heart attacks, blindness, strokes, loss of limbs and kidney function. Most studies on Type 1 diabetes had focused on the immune system, but the Canadian-led team found a link between the disease and the nervous system.
The group discovered that abnormal nerve endings in insulin-producing pancreas islet cells sparked a chain of events that caused Type 1 diabetes in mice. When they removed the sensory neurons, it prevented inflammation of the cells and the mice did not develop the disorder. An injection also cleared islet cell inflammation in afflicted mice within a day and normalized the elevated insulin resistance normally associated with the disease. "We have created a better understanding of both Type 1 and Type 2 diabetes, with new therapeutic targets and approaches derived for both diseases," said study collaborator Pere Santamaria of the University of Calgary. "We are now working hard to extend our studies to patients, where many have sensory nerve abnormalities, but we don't yet know if these abnormalities start early in life and if they contribute to disease development." The treatment is now being tested for Type 2 or obesity-related diabetes, in which insulin resistance is even more severe, with "strong evidence" so far it will work, the researchers said.
最后编辑于 2022-10-09 · 浏览 564
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