【交流】CD8＋ T细胞与病毒疫苗设计

让我们来共同学习一下这个影响因子为52.280的免疫学期刊，对病毒疫苗设计的总结和展望。

杂志:Annual Review of Immunology
日期：Vol. 23: 651-682 (Volume publication date April 2005)
标题：UNDERSTANDING PRESENTATION OF VIRAL ANTIGENS TO CD8+ T CELLS IN VIVO: The Key to Rational Vaccine Design*
作者Jonathan W. Yewdell and ­S.M. Mansour Haeryfar­




CD8+ T cells play a critical role in antiviral immunity by exerting direct antiviral activity against infected cells. Because of their ability to recognize all types of viral proteins, they offer the promise of providing broad immunity to viruses that evade humoral immunity by varying their surface proteins. Consequently, there is considerable interest in developing vaccines that elicit effective antiviral TCD8+ responses. Generating optimal vaccines ultimately requires rational design based on detailed knowledge of how TCD8+ are activated in vivo under natural circumstances. Here we review recent progress obtained largely by in vivo studies in mice to understand the mechanistic basis for activation of naive TCD8+ in virus infections. These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design.

CD8+ T细胞通过对感染细胞的直接杀伤作用而在抗病毒免疫中扮演着重要角色。因其可识别各型的病毒蛋白，这就预示着其对那些通过表面蛋白的变化，对抗体液免疫而侵犯机体的病毒能发挥广谱的免疫作用。因此，不少研究致于研制能激发有效的抗病毒T CD8+反应的疫苗。如何得到合适的疫苗取决于合理的设计，而后者又基于人们对CD8+ T细胞在体内自然环境下是如何被激活的这个机制的了解。在此，我们对在小鼠体内进行的，探讨天然CD8+T细胞在病毒感染中如何被激活的机制的进展，做一综述。这些研究为深入了解这个机制指明了方向，并为疫苗的研制提供了重要的信息，尽管尚有许多有待于进一步了解并最终能真正地设计出合理疫苗。