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【medical-news】【资讯翻译】孕期抗抑郁治疗不会增加后代自闭症的风险

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原文链接： http://www.medicalnewstoday.com/releases/269267.php
Risk of autism not increased by antidepressant medication in pregnancy
New research cannot establish a close connection between the use of antidepressant medication - the so-called SSRIs - during the course of pregnancy and the risk of having a child with autism:
"More and more women are given antidepressant medication while they are pregnant. And an increasing number of children are diagnosed with autism. This has given rise to concern over a possible connection. In contrast to other, smaller studies, our survey cannot demonstrate that the risk of having a child with autism is increased by taking antidepressant medication during pregnancy," says PhD Jakob Christensen, researcher at Aarhus University and staff specialist at Aarhus University Hospital.
Previous research has shown that the risk of having a child with autism is up to five times greater for pregnant women who take antidepressant medication.
Largest study of correlation

In a large register study, Jakob Christensen and his colleagues from Aarhus University and Aarhus University Hospital have followed more than 600,000 Danish children born in the period between 1996-2006. The survey is the largest so far undertaken of the correlation between antidepressant medication during pregnancy and autism.
The initial results of the Danish study showed that there was almost a two percent risk of having a child with autism for pregnant women who take antidepressant medication during their pregnancy. For women who do not take antidepressant medication during pregnancy the risk was 1.5 percent. But the researchers also analysed siblings
and parents' psychiatric diagnoses. And when these are taken into account the risk is shown to be minimal:
"We know from previous studies that there is an increased risk for autism, among other things, if the parents have a mental diagnosis such as depression. But we cannot demonstrate that the risk is further increased if the mother has received prescription antidepressant medication during the pregnancy," says Jakob Christensen, adding:
"By analysing data for siblings we can see that the risk of having a child with autism is largely the same regardless of whether the mother takes antidepressant medication or not during the pregnancy."
The researchers cannot thereby demonstrate that the medication is to blame for autism in children.
Important knowledge
Many women have antidepressant drugs prescribed by their general practitioner. Researcher in general practice Mogens Vestergaard believes that the survey also contains important knowledge for general practitioners:
"Most of the people who receive SSRIs get them through their general practitioner. This was also the case for 80 percent of the women who received antidepressant medication in the study. Of course the results of the survey provide important knowledge for the general practitioners. They are the ones who meet pregnant women who are nervous about the consequences of taking antidepressant medication during their pregnancy," says Professor Mogens Vestergaard from Aarhus University.
The researchers stress that there may be other risks associated with taking antidepressant medication during pregnancy. People should therefore contact their medical doctor in any case if they are under medication and considering becoming pregnant, so that they can receive the best possible advice.
The study has just been published in the internationally recognized journal Clinical Epidemiology.

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2013-11-30 13:15 浏览 : 975 回复 : 7

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认领本文翻译，48小时内未完成，请其他战友认领！

2013-11-30 13:27

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文题Antidepressant exposure in pregnancy and risk of autism spectrum disorders
期刊Clinical epidemiology
PMID: 24255601

CLEpec_111413.pdf(293.68k)

2013-11-30 13:37

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编译字数：1010

孕期使用抗抑郁药物不会增加后代自闭症风险
新的研究不能明确，怀孕期间使用抗抑郁药物——所谓的选择性五羟色胺再摄取抑制剂（注：SSRIs即选择性五羟色胺再摄取抑制剂，是目前首选的抗抑郁药物）与后代自闭症风险具有紧密关系。“怀孕时服用抗抑郁药物的女性越来越多，。同时诊断为自闭症的儿童数量正逐步增加。这让人们担心（两者之间）的可能联系。与其他小样本量的研究相比，我们的调查不能证实，怀孕期间服用抗抑郁药会增加后代患自闭症的风险，奥胡斯大学研究员雅各布?克里斯滕森博士及奥胡斯大学附属医院的专家说。
以往的研究显示，服用抗抑郁药物的孕妇的后代患自闭症风险提高5倍。
样本量最大的相关性研究
在一个大型注册研究中，雅各布?克里斯滕森及其来自奥胡斯大学和奥胡斯大学附属医院的同事，随访了大于600,000名在1996至2006年出生的丹麦儿童。这个调查，是目前研究怀孕期间使用抗抑郁药物与自闭症相关性样本量最大的研究。
丹麦研究的最初结果显示，在怀孕期间服用抗抑郁药物孕妇的后代患自闭症的风险是大约2个百分点。在怀孕期未使用抗抑郁药物女性的后代患自闭症的风险是1.5百分点。但是，研究人员同时还分析了（入组儿童的）兄弟姐妹及父母的精神病诊断情况。当将这些因素都纳入分析后，（在怀孕期间使用抗抑郁药物增加后代患自闭症的）风险行当低。“通过以往的研究我们得以知道，在其他因素中，如果父母亲有精神疾病的诊断如抑郁症，患自闭症的风险会增加。但是我们不能证明（患抑郁症）的母亲在孕期间，服用抗抑郁药物后，会进一步增加后代患自闭症的风险，”雅各布?克里斯滕森说，“通过分析兄弟姐妹的数据，我们发现，不管母亲在怀孕期间是否服用抗抑郁药物，后代患自闭症的风险大体一致。”这样研究人员不能证明，药物应对儿童自闭症负责。
重要信息
很多妇女服用她们全科医师开的抗抑郁药物。全科医学研究人员莫恩斯?韦斯特高认为，该研究还包含对全科医师来说很重要的信息：“大部分人是通过她们的全科医师，得到选择性五羟色胺再摄取抑制剂药物（SSRIs）。这也是本案中百分之八十妇女获得抗抑郁药物的途径。所以当然该研究结果为全科医生提供了重要信息。他们是，为对怀孕期间服用抗抑郁药物后果焦虑不安的孕妇诊治的医师，”奥胡斯大学的莫恩斯?韦斯特高说。研究人员强调可能还有其他风险与孕期服用抗抑郁药物相关。因此正在服用药物又考虑怀孕的人，应与她们的医生沟通，便于得到最佳的建议。
该研究成果刚发表在国际著名期刊《临床流行病学》杂志（《Clinical Epidemiology》）上。

2013-11-30 18:52

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myhuyong 编辑于 2013-11-30 20:49

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