【medical-news】近年非小细胞肺癌肺癌的5年生存率明显改善
The researchers found a marked increase in the postoperative 5-year survival, from 34.1% to 76.5%.
The changes are likely due to earlier diagnosis of adenocarcinoma plus advances in imaging techniques, according to lead author Dr. Takeshi Hanagiri and colleagues from the University of Occupational and Environmental Health in Kitakyushu.
The investigators' findings are based on a review of data on 1487 NSCLC patients who had surgery over a 30-year period. They stratified patients by the era of their surgery: 1979-1988, 1989-1993, 1994-1998, 1999-2003, and 2004-2008.
The number of patients having surgical resection for NSCLC rose from 167 in the earliest era to 429 in the most recent. The percentage of pathologic stage IA lung cancers also increased from 16.2% to 52.0%, with a rapid rise in recent years.
Other trends showed that postoperative 5-year survival rates rose steadily, both for the cohort as a whole (from 34.1% to 76.5%) and for patients with pathologic stage IA lung cancer (70.0% to 88.7%).
Mean tumor diameter shrunk between the first and last periods, from 36.0 to 26.8 mm.
A progressive increase in the percentage of adenocarcinoma was also observed during the five periods: 49.1%, 52.1%, 54.7%, 62.8%, and 69.7%, respectively. The average percentage of adenocarcinoma was 52.2% in the period 1989 to 1998 and 66.5% in the period 1999 to 2008, indicating a significant increase (p < 0.001). On the other hand, the average percentage of squamous cell carcinomas decreased over the same period.
"Early diagnosis remains a key factor for improving the survival of lung cancer patients after surgical treatment," the investigators conclude.
J Thorac Oncol 2010;5:825-829.