【Lancet oncology】研究表明：化学接触增加乳腺癌风险
发布于 2010-04-02 · 浏览 1092 · IP 北京北京
这个帖子发布于 15 年零 33 天前，其中的信息可能已发生改变或有所发展。
研究表明：化学接触增加乳腺癌风险
Study Links Chemical Exposure to Breast CA Risk
原文：
Workplace exposure to organic solvents and certain other chemicals while a woman is still young can increase her risk of breast cancer after menopause, researchers say.
Those who were exposed at work to petroleum byproducts and synthetic fibers such as acrylic and nylon appear to be at the greatest risk, France Labreche, MD, of the Institut de Recherche Robert Sauve in Montreal, and colleagues reported online in Occupational and Environmental Medicine.
And risks appear to be highest when a woman is exposed before age 36, they added.
Environmental and occupational agents may be contributing factors in the etiology of breast cancer, research has shown.
To further the understanding of that etiology, the researchers conducted a case-control study in Montreal between 1996 and 1997. Cases were 556 women with breast cancer who were between the ages of 50 and 75. They were matched with 613 women with other cancers who acted as controls.
Overall, the researchers found an increased risk of breast cancer with occupational exposure to several agents, which was highest when exposures occurred before age 36.
The authors acknowledged that the study was limited by its retrospective design, possible misclassification, and potential recall bias.
Exposure to synthetic fibers, common in the textile industry, carried a particularly high risk of postmenopausal breast cancer.
For each 10-year increase in duration of exposure before age 36, acrylic fibers were associated with a nearly eight-fold risk of breast cancer (OR 7.69), while nylon fibers were associated with a doubled risk (OR 1.99).
Rayon and wool fibers also carried an increased risk of breast cancer associated with early exposures, the researchers said.
The researchers said synthetic fibers are typically treated with several chemicals, such as flame retardants from the organophosphate family, delustering agents, and dyes, some of which have estrogenic properties and may be carcinogenic.
They also found associations with breast cancer for early exposure to polycyclic aromatic hydrocarbons (PAHs) from both petroleum sources and other agents.
There were no associations with aliphatic alcohols, aliphatic aldehydes, alkanes, ammonia, calcium carbonate, insecticides, leaded and unleaded engine emissions, pesticides, polyester fibers, and toluene.
When they analyzed breast cancer by tumor status, the researchers found that exposure to PAHs from petroleum tripled the risk of breast cancer among those with estrogen- and progesterone-positive tumors.
For estrogen-positive and progesterone-negative tumors, risk of breast cancer more than doubled for each 10-year increase in exposure to acrylic fibers, rayon fibers, and monoaromatic hydrocarbons, they found.
The researchers said that overall, the findings are consistent with the hypothesis that breast tissue is more sensitive to adverse effects if exposure occurs when breast cells are still proliferating -- before the fourth decade of life.
原文地址： http://www.medpagetoday.com/Oncology/BreastCancer/19321
Study Links Chemical Exposure to Breast CA Risk
原文：
Workplace exposure to organic solvents and certain other chemicals while a woman is still young can increase her risk of breast cancer after menopause, researchers say.
Those who were exposed at work to petroleum byproducts and synthetic fibers such as acrylic and nylon appear to be at the greatest risk, France Labreche, MD, of the Institut de Recherche Robert Sauve in Montreal, and colleagues reported online in Occupational and Environmental Medicine.
And risks appear to be highest when a woman is exposed before age 36, they added.
Environmental and occupational agents may be contributing factors in the etiology of breast cancer, research has shown.
To further the understanding of that etiology, the researchers conducted a case-control study in Montreal between 1996 and 1997. Cases were 556 women with breast cancer who were between the ages of 50 and 75. They were matched with 613 women with other cancers who acted as controls.
Overall, the researchers found an increased risk of breast cancer with occupational exposure to several agents, which was highest when exposures occurred before age 36.
The authors acknowledged that the study was limited by its retrospective design, possible misclassification, and potential recall bias.
Exposure to synthetic fibers, common in the textile industry, carried a particularly high risk of postmenopausal breast cancer.
For each 10-year increase in duration of exposure before age 36, acrylic fibers were associated with a nearly eight-fold risk of breast cancer (OR 7.69), while nylon fibers were associated with a doubled risk (OR 1.99).
Rayon and wool fibers also carried an increased risk of breast cancer associated with early exposures, the researchers said.
The researchers said synthetic fibers are typically treated with several chemicals, such as flame retardants from the organophosphate family, delustering agents, and dyes, some of which have estrogenic properties and may be carcinogenic.
They also found associations with breast cancer for early exposure to polycyclic aromatic hydrocarbons (PAHs) from both petroleum sources and other agents.
There were no associations with aliphatic alcohols, aliphatic aldehydes, alkanes, ammonia, calcium carbonate, insecticides, leaded and unleaded engine emissions, pesticides, polyester fibers, and toluene.
When they analyzed breast cancer by tumor status, the researchers found that exposure to PAHs from petroleum tripled the risk of breast cancer among those with estrogen- and progesterone-positive tumors.
For estrogen-positive and progesterone-negative tumors, risk of breast cancer more than doubled for each 10-year increase in exposure to acrylic fibers, rayon fibers, and monoaromatic hydrocarbons, they found.
The researchers said that overall, the findings are consistent with the hypothesis that breast tissue is more sensitive to adverse effects if exposure occurs when breast cells are still proliferating -- before the fourth decade of life.
原文地址： http://www.medpagetoday.com/Oncology/BreastCancer/19321
最后编辑于 2022-10-09 · 浏览 1092
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