【medical-news】研究显示:呼吸道病毒感染为亚洲儿童哮喘恶化的常见原因
发布于 2010-03-08 · 浏览 1037 · IP 香港香港
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MedWire News: Respiratory viral infections are commonly associated with asthma exacerbations in Asian children, research suggests.
“Up to 80% of asthma exacerbations in White children are associated with viral upper respiratory infections,” explain Ting Fan Leung (Prince of Wales Hospital, Hong Kong, China) and team in the journal Chest.
However, they add that data on the relative importance of different respiratory pathogens in asthma exacerbations among Asian children is limited.
To address this, the researchers studied 286 asthmatic children, aged 3–18 years, living in Hong Kong between 2007 and 2008. Of these, 209 had recently suffered an asthma exacerbation and 77 had stable disease (controls).
Nasopharyngeal aspirates were collected from the children and assessed for 20 different respiratory pathogens using nested multiplex polymerase chain reaction, and all participants aged at least 6 years underwent exhaled nitric oxide and lung function measurements. Global Initiative for Asthma guidelines were used to assess the severity of asthma exacerbations.
Overall, respiratory pathogens were detected in 51.0% of children with an asthma exacerbation compared with 27.3% of those with stable asthma.
Initial analysis revealed that the presence of any pathogen was associated with an increased risk for asthma exacerbation, at an odds ratio (OR) of 2.77. However, further analysis revealed that only human rhinovirus (HRV) infection was significantly associated with asthma attacks, at an OR of 2.38. Indeed, this virus was detected in 46.4% of children with asthma exacerbations during the winter season.
None of the assessed respiratory pathogens were associated with the severity of asthma exacerbations, the researchers note.
Fan Leung and team conclude: “Respiratory viruses and atypical bacteria are detected in more than half of Hong Kong children with asthma exacerbation. HRV infection is the most important risk factor for asthma exacerbation in these patients. Nonetheless, none of these pathogens is associated with severity of asthma exacerbation.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
“Up to 80% of asthma exacerbations in White children are associated with viral upper respiratory infections,” explain Ting Fan Leung (Prince of Wales Hospital, Hong Kong, China) and team in the journal Chest.
However, they add that data on the relative importance of different respiratory pathogens in asthma exacerbations among Asian children is limited.
To address this, the researchers studied 286 asthmatic children, aged 3–18 years, living in Hong Kong between 2007 and 2008. Of these, 209 had recently suffered an asthma exacerbation and 77 had stable disease (controls).
Nasopharyngeal aspirates were collected from the children and assessed for 20 different respiratory pathogens using nested multiplex polymerase chain reaction, and all participants aged at least 6 years underwent exhaled nitric oxide and lung function measurements. Global Initiative for Asthma guidelines were used to assess the severity of asthma exacerbations.
Overall, respiratory pathogens were detected in 51.0% of children with an asthma exacerbation compared with 27.3% of those with stable asthma.
Initial analysis revealed that the presence of any pathogen was associated with an increased risk for asthma exacerbation, at an odds ratio (OR) of 2.77. However, further analysis revealed that only human rhinovirus (HRV) infection was significantly associated with asthma attacks, at an OR of 2.38. Indeed, this virus was detected in 46.4% of children with asthma exacerbations during the winter season.
None of the assessed respiratory pathogens were associated with the severity of asthma exacerbations, the researchers note.
Fan Leung and team conclude: “Respiratory viruses and atypical bacteria are detected in more than half of Hong Kong children with asthma exacerbation. HRV infection is the most important risk factor for asthma exacerbation in these patients. Nonetheless, none of these pathogens is associated with severity of asthma exacerbation.”
MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010
最后编辑于 2010-03-08 · 浏览 1037
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