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【drug-news】Plavix 停药后心脏病发作风险可能再度提高

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February 6, 2008, 8:44 am
Heart Attack Risk May Rebound After Halting Plavix
Posted by Jacob Goldstein

Can the blood grow dangerously accustomed to a blood thinner? Perhaps, according to a study that found the risk of heart attack or death jumped when patients went off the popular blood thinner Plavix.

Researchers looked back at more than 3,000 patients who took Plavix after being treated for heart attack or unstable angina. The patients, who were discharged from VA hospitals between 2003 and 2005, took Plavix for about 10 months after leaving the hospital. The risk of heart attack and death was nearly twice as high in the 90 days after going off the drug relative to later months.

The authors say this could be a sort of “rebound” effect, and point to evidence from lab studies that suggests the blood may have a stronger-than-normal tendency to clot immediately after a patient goes off of an anti-clotting drug.

They also consider the possibility that the increased risk could simply be a function of still being at risk for another heart attack. But they discount this, noting that the risk increased after patients went off the drug whether they had been taking it for three, six, nine or more than nine months. They didn’t have enough patients who took Plavix for 12 or15 months — which has recently become more common — to see what the risks were in those groups, the Washington Post notes.

The authors conclude that the findings don’t necessarily offset the benefits of the drug, the WSJ notes. But they suggest it might be worth reconsidering the length of time patients take Plavix, and how they are taken off the drug (which is co-marketed by Sanofi-Aventis and Bristol-Myers Squibb).

Meanwhile, we’ll be curious to see what the profile looks like for prasugrel, Lilly’s new blood thinner that’s currently before the FDA.

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2008-02-07 11:32 浏览 : 1016 回复 : 1

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Can the blood grow dangerously accustomed to a blood thinner? Perhaps, according to a study that found the risk of heart attack or death jumped when patients went off the popular blood thinner Plavix.
适应了抗血小板药物的血细胞是否会危险地增长？有可能，根据一项研究发现：当患者停用了常用抗血小板药物波立维后，心脏突发事件或死亡率会突然增长。
Researchers looked back at more than 3,000 patients who took Plavix after being treated for heart attack or unstable angina. The patients, who were discharged from VA hospitals between 2003 and 2005, took Plavix for about 10 months after leaving the hospital. The risk of heart attack and death was nearly twice as high in the 90 days after going off the drug relative to later months.
研究者回顾了大约3000名患者，这些患者因突发心脏病或不稳定型心绞痛而口服波立维。这些患者都是于2003年-2005年从VA医院出院，出院后口服波立维10个月。停药90天内突发心脏病风险和死亡风险大约两倍于停药前的最后几个月。
The authors say this could be a sort of “rebound” effect, and point to evidence from lab studies that suggests the blood may have a stronger-than-normal tendency to clot immediately after a patient goes off of an anti-clotting drug. 作者认为这可能是一种反跳效应，并指出根据实验室证据，如果患者停用某一种抗凝药，血细胞可能具有强于正常的迅速凝结的倾向。
They also consider the possibility that the increased risk could simply be a function of still being at risk for another heart attack. But they discount this, noting that the risk increased after patients went off the drug whether they had been taking it for three, six, nine or more than nine months. They didn’t have enough patients who took Plavix for 12 or15 months — which has recently become more common — to see what the risks were in those groups, the Washington Post notes
华尔街日报记者还设想：危险增长的可能性可能只是由于存在另一种心脏突发事件风险的影响。但是他们又不完全相信，指出患者口服3个月，6个月，9个月及大于9个月后停药，风险是随之增长的。他们没有足够的口服波立维12-15个月的患者，去观察这些患者面临的风险---这类病人近来变得越来越普遍。
The authors conclude that the findings don’t necessarily offset the benefits of the drug, the WSJ notes. But they suggest it might be worth reconsidering the length of time patients take Plavix, and how they are taken off the drug (which is co-marketed by Sanofi-Aventis and Bristol-Myers Squibb).
华尔街日报总结认为该发现并不能抵消药物带来的获益，但是他们建议重新考虑患者口服波立维的疗程，以及怎样停药是非常有必要的（药物经销商为赛诺菲-安万特公司及百时美-施贵宝公司）。
Meanwhile, we’ll be curious to see what the profile looks like for prasugrel, Lilly’s new blood thinner that’s currently before the FDA.
同时，我们将关注有关prasugrel的评论， prasugrel是礼来公司的抗血小板新药，目前准备FDA认证。

2008-02-13 01:26

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• 记抗菌谱？除了背口诀，还有这种好方法！

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